Molecular Basis of Inheritance


  1. The association of histone H1 with a nucleosome indicates:









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    The association of H1 protein indicates the complete formation of nucleosome which requires DNA condensation. The DNA is therefore in condensed form.

    Correct Option: B

    The association of H1 protein indicates the complete formation of nucleosome which requires DNA condensation. The DNA is therefore in condensed form.


  1. Which one of the following is not applicable to RNA?









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    Chargaff’s rule is not applicable to RNA

    Correct Option: C

    Chargaff’s rule is not applicable to RNA



  1. Transformation was discovered by:









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    Frederick Griffith (in 1928), a British Medical officer described the phenomenon of bacterial transformation. He carried out experiment with Streptococcus pneumoniae (bacterium causing pneumonia) which is used to infect mice. By using S Strain (heat killed) and R strain (live) it was concluded that R strain has been transformed by some material of S strain which makes R strain virulent and enable to synthesize smooth polysachharide.

    Correct Option: C

    Frederick Griffith (in 1928), a British Medical officer described the phenomenon of bacterial transformation. He carried out experiment with Streptococcus pneumoniae (bacterium causing pneumonia) which is used to infect mice. By using S Strain (heat killed) and R strain (live) it was concluded that R strain has been transformed by some material of S strain which makes R strain virulent and enable to synthesize smooth polysachharide.


  1. During transcription, RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure, what is it’s DNA-binding sequence?









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    The DNA binding sequence for RNA polymerase is called TATA box.

    Correct Option: C

    The DNA binding sequence for RNA polymerase is called TATA box.



  1. In sea urchin DNA, which is double stranded, 17% of the bases were shown to be cytosine. The percentages of the other three bases expected to be present in this DNA are:









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    Chargaff’s rule states that A = T and G ≡ C. The molar amount of adenine = molar amount of thymine. The molar amount of guanine = molar amount of cytosine.
    Hence, G is 17%, so,
    C = 17% A = 33%,
    so, T = 33%

    Correct Option: B

    Chargaff’s rule states that A = T and G ≡ C. The molar amount of adenine = molar amount of thymine. The molar amount of guanine = molar amount of cytosine.
    Hence, G is 17%, so,
    C = 17% A = 33%,
    so, T = 33%