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Microbiology Miscellaneous

  1. The lipopolysaccharides present in bacterial cell wall has lipid A which is connected to ​​
    1. O-polysaccharide ​​
    2. core polysaccharide
    3. both with O-polysaccharide and core polysaccharide
    4. ​rhamnose-mannose disaccharide ​
Correct Option: B

The Gram negative cell envelope contains an additional outer membrane composed by phospholipids and lipopolysaccharides which face the external environment. The highly charged nature of lipopolysaccharide confers an overall negative charge to the Gram negative cell wall. Lipopolysaccharide is comprised of a hydrophilic polysaccharide and a hydrophobic component known as lipid A which is responsible for the major bioactivity of endotoxin. Lipopolysaccharide can be recognized by immune cells as a pathogen-associated molecule through Toll-like receptor 4. Lipid A usually gets attached to the core polysaccharide of Gram negative cell wall. ​



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