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Match the viruses in Group I with their host cell receptors in Group II.
Group I Group II P. Hepatitis A virus 1. Heparan sulphate Q. Human immunode-ficiency virus 2. Acetylcholine receptor R. Rabies virus 3. CD4 protein S. Herpes simplex virus type I 4. Alpha-2 macroglobulin
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- P Q R S
1 3 2 4 - P Q R S
3 4 1 2 - P Q R S
4 3 2 1 - P Q R S
2 3 1 4
- P Q R S
Correct Option: C
Hepatitis A virus (HAV), an atypical Picornaviridae that causes acute hepatitis in humans, usurps the HAV cellular receptor 1 (HAVCR1) to infect cells. HAVCR1 is a class 1 integral membrane glycoprotein that contains two extracellular domains: a virus-binding immunoglobulin-like (IgV) domain and a mucin-like domain that extends the IgV from the cell membrane. One of the early hallmarks of HIV infection is the impairment of a variety of CD4+ T-cell functions including T-cell colony formation, autologous mixed lymphocyte reactions, expression of interleukin-2 (IL-2) receptors, and IL-2 production. The nicotinic acetylcholine receptor (nAChR) is the first identified receptor for rabies virus. Rabies virus antigen was detected at sites coincident with nAChR. The nicotinic acetylcholine receptor (nAchR) is located at the postsynaptic muscle membrane. Heparan sulfate is a ubiquitously distributed polysulfated polysaccharide that is involved in the initial step of herpes simplex virus type 1 (HSV-1) infection. The virus interacts with cell-surface heparan sulfate to facilitate host-cell attachment and entry. 3-O-Sulfonated heparan sulfate has been found to function as an HSV-1 entry receptor.