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Determine the correctness or otherwise of the following Assertion (A) and the Reason (R).
Assertion : IgM is found in serum as a pentameric protein consisting of five IgM monomers.
Reason : The pentameric form of IgM is due to cross-linking of IgM monomers via peptide bond.
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- both (A) and (R) are true and (R) is the correct reason for (A)
- both (A) and (R) are true but (R) is not the correct reason for (A)
- (A) is true but (R) is false
- (A) is false but (R) is true
Correct Option: C
Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to antigen. The spleen is the major site of specific IgM production.the same time because the large size of most antigens hinders binding to nearby sites.
