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Triose phosphate isomerase converts dihydroxy acetone phosphate (DHAP) to glyceraldehyde-3-phosphate (G-3-P) in a reversible reaction. At 298 K and pH 7.0, the equilibrium mixture contains 40 mM DHAP and 4 mM G-3-P. Assume that the reaction started with 44 mM DHAP and no G-3-P. The standard free-energy change in kJ/mol for the formation of G-3-P [R = 8.315 J/mol.K] is _________.
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- 3.55 to 3.70
- 2.46 to 2.50
- 4.95 to 5.00
- 7.35 to 7.40
Correct Option: B
The standard Gibb's free energy change for the formation of G-3-P is given by:
∆G° = - RT lnK
⇒ ∆G° = - 8.315 × 298 × ln 0.4
⇒ ∆G° = 2,270.449 J/mol = 2.27 kJ/mol
