Which of the following cases are likely to lead to faster

Which of the following cases are likely to lead to faster rates of catalysis by an enzyme immobilized on a negatively charged support?

1. A positively charged substrate and a negatively charged product
2. A negatively charged substrate and a positively charged product
3. A positively charged substrate and a positively charged product
4. All of the above
5. None of the above

It creates the substrate based higher influx leading to a positively charged substrate and a negatively charged product.