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Identical sized RNA transcript is detected by Northern blot analysis of UDP glucuronosyl transferase obtained from human liver and kidney. Microarray analysis of the same samples shows equal spot intensity, ohereas Western blot detects a 55 kDa strong band in liver, but a very faint band in kidney of same size. The regulation of UDP glucuronosyl transferase is
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- transcriptionally controlled
- post-transcriptionally controlled
- translationally controlled
- post-translationally controlled
Correct Option: B
Regulation of UDP glucuronosyl transferase is the result of differential UGT gene expression and this is in response to those chemicals that are primarily eliminated by conjugation with glucuronic acid and hence more evident in liver and hence it can be stated that its regulation is post transcriptionally controlled.
