In a mouse genome, the numbers of functional Vα, Jα, Vβ,

Home » Immunology » Immunology Miscellaneous » Question

In a mouse genome, the numbers of functional V_α, J_α, V_β, D_β, J_β gene segments are 79, 38, 21, 2 and 11, respectively. The total number of possible combinations for αβ T cell receptors are ___×10⁶.

1. 1.38 to 1.80
2. 2.78 to 3.90
3. 1.38 to 1.40
4. 0.08 to 1.80

Correct Option: C

Given, Number of functional gene segments, V_α = 79
Number of functional gene segments, J_α = 38
Number of functional gene segments, V_β = 21
Number of functional gene segments, D_β = 2
Number of functional gene segments, J_β = 11
So, total number of possible combinations for α and β chains are:
(⁷⁹C × ³⁸C) + (²¹C × ²C × ¹¹C) = 1.375 × 10⁶