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In ABO blood group system, antigenic determinants are
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- nucleic acid
- carbohydrate
- lipid
- protein
Correct Option: B
The sequence of oligosaccharides determines whether the antigen is A, B, or A1. The ABO blood group antigens are attached to oligosaccharide chains that project above the RBC surface. These chains are attached to proteins and lipids that lie in the RBC membrane. The ABO locus has three main allelic forms: A, B, and O. The A allele encodes a glycosyltransferase that produces the A antigen (N-acetylgalactosamine is its immunodominant sugar), and the B allele encodes a glycosyltransferase that creates the B
antigen (D-galactose is its immunodominant sugar). The O allele encodes an enzyme with no function, and therefore neither A or B antigen is produced, leaving the underlying precursor (the H antigen) unchanged. These antigens are incorporated into one of four types of oligosaccharide chain, type 2 being the most common in the antigen-carrying molecules in RBC membranes. Thus, in ABO system of blood grouping, the antigenic determinants are of carbohydrate origin.