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Sickle cell anaemia is:
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- caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
- caused by a change in a single base pair of DNA
- characterized by elongated sickle like RBCs with a nucleus
- an autosomal linked dominant trait
Correct Option: B
Sickle cell anaemia is caused by a change in a single base pair of DNA. Sickle-cell anaemia is the name of a specific form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS. Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells flexibility and results in a risk of various complications. ‘
