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All enzymes of TCA cycle are located in the mitochondrial matrix except one which is located in inner mitochondrial membranes in eukaryotes and in cytosol in prokaryotes. This enzyme is
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- isocitrate dehydrogenase
- malate dehydrogenase
- succinate dehydrogenase
- lactate dehydrogenase.
Correct Option: C
Succinate: ubiquinone oxidoreductase, also known in mitochondria as complex II, provides a link between the citric acid cycle and the membrane-bound electron-transport system. The membrane extrinsic, water-soluble domain, known as succinate dehydrogenase (SDH), contains the fumarate/succinate active site with a covalently bound FAD group and three iron-sulfur clusters: [2Fe-2S]2 +/1+, [4Fe- 4S]2+/1+, and [3Fe-4S]1 +/0. The enzyme catalyzes the interconversion of fumarate and succinate, and is closely related to fumarate reductase.