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Determine the correctness or otherwise of the following Assertion (A) and the Reason (R).
Assertion : N-methyl-N’-nitro-N-nitrosoguanidine (NTG) is an effective chemical mutagen.
Reason : Mutations induced by NTG mainly are the GC → AT transitions.
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- both (A) and (R) are true and (R) is the correct reason for (A)
- both (A) and (R) are true but (R) is not the correct reason for (A)
- (A) is true but (R) is false
- (A) is false but (R) is true
Correct Option: A
N-methyl-N’-nitro-N-nitrosoguanidine is a highly reactive chemical that
introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. This substance is reasonably anticipated to be a human carcinogen. The mutations induced by this mutagen are mostly purine-pyrimidine transitions of GC → AT.
