-
Match the following antibiotics in Group I with their mode of action in Group II
Group I Group II P. Chloramphenicol 1. 0Binds to DNA gyrase 1 Q. Norfloxacin 2. Binds to RNA Polymerase R. Puromycin 3. Inhibits peptidyl transferase S. Rifampicin 4. Mimics aminoacyl tRNA
-
- P-1, Q-3, R-2, S-4
- P-3, Q-1, R-2, S-4
- P-3, Q-1, R-4, S-2
- P-4, Q-2, R-3, S-1
Correct Option: C
Chloramphenicol binds to the peptidyl transferase enzyme to inhibit transfer of the growing polypeptide to the next amino acid occupying the “Acceptor” site. Norfloxacin is a nalidixic acid analogue and one of the most potent DNA gyrase inhibitors. Puromycin is a secondary metabolite of Streptomyces alboniger that blocks protein biosynthesis. Puromycin is a structural analogue of the 32 end of aminoacyl-transfer RNA. Rifampicin inhibits bacterial RNA polymerase by binding to the beta subunit of RNA polymerase.
