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RNA is very much susceptible to hydrolysis in alkali because
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- It contains uracil residues in its structure
- Its 2′ -OH group participate in intramolecular cleavage of phosphodiester backbone
- Cleavage occurs in the glycosylic bonds of purine bases
- Cleavage occurs in the glycosylic bonds of pyrimidine bases
Correct Option: B
While DNA contains deoxyribose, RNA contains ribose (in deoxyribose there is no hydroxyl group attached to the pentose ring in the 2′ position). These hydroxyl groups make RNA less stable than DNA because it is more prone to hydrolysis.
