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  1. Which one of the following statements regarding G proteins is INCORRECT?
    1. GDP is bound to G protein in the resting stage
    2. GTP bound a subunit cannot reassemble with βγ dimer
    3. All G proteins are trimeric
    4. Activation of G protein may result in activation or inhibition of the target enzymes
Correct Option: C

All G proteins are not trimeric. GPCR dimerization also was proposed to participate in arrestin-mediated desensitization based on the size of the cytoplasmic tip of rhodopsin and the presence of two cup-like domains in arresting both of which were implicated in receptor binding which one arrestin binds to two receptors in a dimer.



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