-
Which one of the following statements regarding G proteins is INCORRECT?
-
- GDP is bound to G protein in the resting stage
- GTP bound a subunit cannot reassemble with βγ dimer
- All G proteins are trimeric
- Activation of G protein may result in activation or inhibition of the target enzymes
Correct Option: C
All G proteins are not trimeric. GPCR dimerization also was proposed to participate in arrestin-mediated desensitization based on the size of the cytoplasmic tip of rhodopsin and the presence of two cup-like domains in arresting both of which were implicated in receptor binding which one arrestin binds to two receptors in a dimer.