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Choose the correct signal transduction pathway.
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- Hormone → 7 TM receptor → G protein → cAMP → PKA
- Hormone → G protein → 7 TM receptor → cAMP → PKA
- Hormone → 7 TM receptor → G protein → PKA → cAMP
- Hormone → 7 TM receptor → cAMP → G protein → PKA
Correct Option: A
In the G protein associated signal cascade system, binding of hormone to a cell surface receptor, like the 7TM (a 7 transmembrane alpha helices) which is a part of G protein. This will activate production of second messengers like cAMP by the enzyme adenylate cyclase. The cAMP in turn binds and activates down stream signal proteins line cAMP dependent protein kinase A (PKA).
