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Identify the following antibiotics with their modes of action.
Antibiotic
A. Ampicillin
B. Tetracycline
C. Nystatin
D. Anthramycin
Mode of action
1. inhibition of protein synthesis
2. inhibition of cell wall synthesis
3. damage to cytoplasmic membrane
4. damage to DNA structure
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- A → 1, B → 2, C → 4, D → 3
- A → 2, B → 1, C → 3, D → 4
- A → 1, B → 2, C → 3, D → 4
- A → 3, B → 4, C → 2, D → 1
Correct Option: B
Ampicillin inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis.
Nystatin forms pores in the membrane that lead to K+ leakage and death of the fungus. Tetracycline antibiotics are protein synthesis inhibitors, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex.
Anthramycin exerts its biological activity through covalent binding to the C2-NH2 of guanine within the minor groove of DNA thus damaging the actual structure.
