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Examination of blood of a person suspected of having anemia, shows large, immature, nucleated erythrocytes without haemoglobin. Supple-menting his diet with which of the following, is likely to alleviate his symptoms?
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- Folic acid and cobalamine
- Riboflavin
- Iron compounds
- Thiamine
Correct Option: A
Folic Acid (Cyanocobalamine vit. B12) works in the formation and maturation of RBCs. In its deficiency RBC formation decreases and the formed RBCs will not mature i.e. they will not loose the nucleus and hence remain nucleated and lack haemoglobin. Such RBCs cannot carry oxygen & person suffers from anaemia. Supplementing his diet with folic acid and cobalamine will lead to the increased formation and proper maturation of enucleated RBCs with haemoglobin and eliminate anaemia.
