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  1. Sickle cell anaemia is characterised by
    1. Leukemia
    2. Polycythemia
    3. Mental retardation
    4. Hemolytic anaemia
Correct Option: D

In sickle cell anaemia, normal haemoglobin (HbA) gets changed in denatured form of haemoglobin (HbS) in which the haemoglobin molecule’s configuration changes and it changes its shape, in low O2 concentration unable to transport O2 transportation and RBCs become sickle shaped. It is a genetic disease caused by the denaturation of haemoglobin, that is why it is known as hemolytic anaemia.



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