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Changes in GnRH pulse frequency in females is controlled by circulating levels of
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- estrogen and progesterone
- estrogen and inhibin
- progesterone only
- progesterone and inhibin
Correct Option: A
At the pituitary, GnRH stimulates the synthesis and secretion of the gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from progesterone and estrogens. Lowfrequency GnRH pulses are required for FSH release, whereas high-frequency GnRH pulses stimulate LH pulses in a one to one manner.