Correct Option: B

The smallpox vaccine was the first successful vaccine to be developed. The process of vaccination was first publicised by Edward Jenner in 1796, who acted upon his observation that milkmaids who caught the cowpox virus did not catch smallpox. The vaccine consists of the virus which causes the related, yet far milder, cowpox disease; this virus is named vaccinia (the term vaccine is derived from it), from the Latin vacca which means cow. This vaccine has functional viruses in it. Vaccines generally consist of a weakened (attenuated) or killed antigens, associated with a particular disease that are capable of stimulating the body to make specific antibodies to that disease. Vaccines use a variety of different substances ranging from dead microorganisms to genetically engineered antigens to defend the body against potentially harmful microorganisms. Effective vaccines change the immune system by promoting the development of antibodies that can quickly and effectively attack a disease causing microorganism when it enters the body, preventing disease development.