Hypophosphatemia is manifested by an X-linked dominant allele.What

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Hypophosphatemia is manifested by an X-linked dominant allele.What proportion of the offsprings from a normal male and an affected heterozygous female will manifest the disease?

1. ½ sons and ½ daughters
2. all daughters and no sons
3. all sons and no daughters
4. ¼ daughters and ¼ sons

Correct Option: A

Given, Hypophosphatemia is caused due to X-linked dominant allele. Now, when a normal male (XY) and a diseased female (X^HX) are crossed together, the F1 generation will have offspring : XX, X^HX, XY and X^HY. So from this it can be seen that half of the male offspring and half of the female offspring bear the diseased allele.