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Which one of the following monolayer culture systems have the highest surface area: medium ratio?
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- Roux bottle
- Spiracell roller bottle
- Hollow fibres
- Plastic bag/film
Correct Option: C
Hollow fibers also provide a tremendous amount of surface area in a small volume. Cells grow on and around the fibers at densities of greater than 1 x 108 per mL.
Hollow fiber cell culture is the only means to culture cells at in vivo like cell densities.
