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Biochemical Miscellaneous

  1. The precursor for penicillin-G biosynthesis during fermentation process is
    1. ​Phenylacetic acid ​​
    2. Phenoxyacetic acid
    3. Acetic acid
    4. None of these ​
Correct Option: A

Penicillium chrysogenum utilizes phenylacetic acid as a side chain precursor in penicillin G biosynthesis. During industrial production of penicillin G, phenylacetic acid is fed in small amounts to the medium to avoid toxic side effects. Phenylacetic acid is taken up from the medium and intracellularly coupled to 6-aminopenicillanic acid.



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