Correct Option: A

​Several types of DNA library resources were sponsored by the DOE before and during the Human Genome Program (HGP).  These included both prokaryotic and eukaryotic vector systems, and clone libraries representing single chromosomes.  Bacterial Artificial Chromosomes (BACs) became the most broadly used resource for several reasons.  The large size was a good match for capabilities of high throughput sequencing centres. A bacterial artificial chromosome (BAC) is an engineered DNA molecule used to clone DNA sequences in bacterial cells (for example, E. coli). BACs are often used in connection with DNA sequencing. Segments of an organism’s DNA, ranging from 100,000 to about 300,000 base pairs, can be inserted into BACs. The BACs, with their inserted DNA, are then taken up by bacterial cells. As the bacterial cells grow and divide, they amplify the BAC DNA, which can then be isolated and used in sequencing DNA.