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Which of the following has been produced commercially from mammalian cell cultures?
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- Plasminogen activator
- Antibacterial antibiotics
- Insulin
- Renin
Correct Option: A
plasminogen activator - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis. The approval of Chinese hamster ovary (CHO)-derived tissue plasminogen activator (tPA, Activase) in 1986 revolutionized medicine and raised the possibility of using mammalian cell culture for the manufacturing of protein therapeutic products.
